When the BAU investigates incidents of bodies being incorporated into macabre graffiti art in Detroit, they suspect an elusive yet notorious street artist could be the killer. Also, Lewis struggles to balance her relationship with her fiancé and her work.
- Marina Benedict - Ellen Clark
- Phillip Andre Botello - Markus Ivey
- Zack Duhame - Corey Marlin
- Rob Kirkland - Doug Fuller
- Michelle Lawrence - Katherine Wallace
- David L.M. McIntyre - Leonard Ennis
- Mark Meir - Stuart Wallace
- Darryl Reeves - Russell Pearson
- Johnny Sneed - William Cochran
- Aisha Tyler - Doctor Tara Lewis
- Tom Wright - Chief Aaron Palmer
- "Non Piu Andrai" by Lorenzo da Ponte
- Spencer Reid: "Ghosts were created when the first man woke in the night." – J.M. Barrie
- Tara Lewis: A Spanish proverb says, "More grows in the garden, than the gardener knows he has planted."
- In Garcia's computer screen, a logo of the fictional airline Trans Alliance Airlines can be seen; one of its airliners was hacked into and crashed by a homegrown terrorist in "A Thousand Suns", an episode from the previous season.