- Jayne Atkinson - FBI Section Chief Director Erin Strauss
- David Bickford - Doctor Montgomery Houston
- Andrew Bowen - Mark Jackson
- Patrick Breen - Peter Harper
- Nicholas Brendon - Analyst Kevin Lynch
- Cici Leah Campbell - Tina
- William Charlton - Detective Paul Boseman
- Elizabeth Higgins Clark - Tammy
- Aubree Garmon - Swimmer
- Ayumi Iizuka - Call Center Operator
- Ally Iseman - Laurel Tyson
- Trevor Jackson - Tyler Rogers
- Stephanie Jones - Leslie Hopkins
- Genevieve Levin - Alicia Danner
- Mino Mackic - Detective
- Lauren Marie - Kayla Jefferson
- Gita Reddy - M.E. Marvi Hatcher
- Stephen Simon - Sam
- Sean Solan - John Butler
- Jacquelyn Zook - Nicole Francis
- "Let It Be Me" by Ray LaMontagne
- Spencer Reid: Barbara Grizzuti Harrison once said, "All acts performed in the world begin in the imagination."
- Spencer Reid: Oscar Wilde said, "I can resist anything except temptation."
- Stephen Simon, the actor who portrays Sam, previously appeared on Criminal Minds in the Season Six episode Reflection of Desire, starring as Clarence.
- Cici Leah Campbell, the actress who portrays Tina, previously appeared on Criminal Minds in the Season Eight premiere episode The Silencer, starring as a victim of John Myers.