- Aisha Alfa - Allie Leighton
- Tristan Byon - Joe Miller
- Camille Chen - Joanna Miller
- Andrea Cortes - Mia
- Meagen Fay - Irene Jacobs
- Angela Fornero - Paige Burrell
- Darrell Hammond - Lawrence Coleman
- Summer Rose Ly - Chrissy Miller
- Kimleigh Smith - Doctor Roberta Childs
- Christine Weatherly - Lacy
- Michael Whaley - Captain Chuck Skinner
- "See Again" by Scott Middough
- Spencer Reid: T. S. Eliot wrote, "This is the way the world ends. Not with a bang, but a whimper."
- Jennifer Jareau: "Even if I knew that tomorrow the world would go to pieces, I would still plant my apple tree." – Martin Luther
- Aisha Tyler is the fourth actor from the show's main cast to direct an episode, the first being Matthew Gray Gubler, the second being Thomas Gibson, and the third being Joe Mantegna.
- Although this was the fifth produced episode in the season, it is being aired as the sixth.