The BAU pursues a religious killing team in Atlanta that sets up computer webcams to record their murders and post them on the Internet. As the team closes in on the unsubs, Reid faces a life-threatening situation.
- Keisha Alfred - Gayle Gentry
- Brian Appel - Agent Grant Anderson
- James Van Der Beek - Tobias Hankel
- Cullen Douglas - Doctor Tony Wilson
- McKinley Freeman - Agent Franks
- Todd Grinnell - Dennis Kyle
- Phinneas Kiyomura - Another Darts Player
- Dean Lemont - Agent Travis Green
- Meredith Monroe - Haley Hotchner
- Wolf Muser - Samuel
- Jim Nantz - Himself
- Jaime Ray Newman - Lacy Kyle
- Tyler Olson - Handyman
- K'Sun Ray - Young Tobias Hankel
- Gina Garcia Sharp - CSU Tech Agent Gina Sharp
- Phil Simms - Himself
- Samantha Smith - Helen Douglas
- Bill Smitrovich - Detective Farraday
- Don Swayze - Charles Hankel
- Karl T. Wright - Ken Gentry
- "Push It" by Rick Ross
- Jason Gideon: Condemned murderer Perry Smith said of his victims, the Clutter family, "I didn't have anything against them, and they never did anything wrong to me, the way other people have all my life. Maybe they're just the ones who have to pay for it."
- This episode was a special broadcast chosen to air after CBS's coverage of Super Bowl XLI. It attracted 26.2 million viewers (according to Nielsen preliminary numbers), which is the highest amount of viewers for a Criminal Minds episode in the show's history. Appropriately enough, the episode is titled "The Big Game".
- Edward Allen Bernero made an uncredited cameo in this episode, appearing as a man in the bar the BAU are gathered at.
- Phinneas Kiyomura, the actor who played one of the darts players, previously appeared in an earlier episode of Criminal Minds, starring as a medic in the Season One episode Derailed.