The BAU travels to the Midwest to track down a spree killer who is targeting families in Nebraska and Iowa. Meanwhile, a troubled Ellie Spicer runs away from her foster family to visit Morgan in Quantico.
- Sterling Beaumon - Jeremy Sayer
- Michael Reilly Burke - Agent Grady Beeks
- Kristin Carey - Sandra Bennett
- William Cowart - Reverend Louis Hannum
- Chloe Csengary - Carrie Sayer
- Evan Dye - Zack Riverton
- David Goryl - Jake Bennett
- Stephanie Katherine Grant - Amber Riverton
- Natalie Alyn Lind - Kayla Bennett
- Kenneth Meseroll - State Trooper
- Cameron Meyer - Ellie's Mom
- Isabella Murad - Ellie Spicer
- Kerry O'Malley - Kendra Sayer
- Preston Strother - Sammy Bennett
- Mare Winningham - Nancy Riverton
- "Moneygrabber" by Fitz and the Tantrums
- "In One Ear" by Cage the Elephant
- "Waltz C Minor Op 64" by APM
- "System Overload" by the P Jayz
- "Cooler Than Me" by Mike Posner
- "House of Wax" by Wax Tailor
- "Why Don't You Love Me" by the Dahls
- "Nobody Hot As Me" by KU
- Derek Morgan: "All humanity is one undivided and indivisible family. I cannot detach myself from the wickedest soul." Mahatma Gandhi
- Derek Morgan: "But I have promises to keep, and miles to go before I sleep, and miles to go before I sleep." Robert Frost
- Michael Reilly Burke, who portrays FBI agent Grady Beeks, has previously portrayed real-life serial killer Ted Bundy in the 2002 movie of the same name.
- "Safe haven" is an alternate term for a sanctuary. It can also be used to refer to the safe-haven law, which is referenced in the episode.
- Kenneth Meseroll, the actor who portrayed a state trooper, previously appeared on an earlier episode of Criminal Minds, starring as Mayor Gregory Hughes in the Season Two episode Fear and Loathing.