Little is known about Rodriguez's early life. In 2001, she wrote, produced, and directed a feature film called Acts of Worship, which is about a young woman struggling with drug addiction. The film was nominated for, and won, numerous indie film awards as well as awards from film festivals such as St. Louis International, Santa Barbara International, and Magnolia Independent. Rodriguez has also worked as a director on many U.S. TV series, including Third Watch, Law & Order, Rescue Me, Castle, Criminal Minds, Undercovers, Without a Trace, and Elementary. Recently, she has directed episodes of two critically-acclaimed CBS-produced drama shows, The Good Wife and Blue Bloods.