- Charlene Amoia - Nancy Scott
- Sam Anderson - Doctor Rawlings
- Jon Barton - SWAT Leader
- Marc Bossley - Fire Captain Daniel Wales
- Gary Castro Churchwell - Jason Elliott
- Mark Costello - Gary Grimshaw
- Mark Daneri - Minister
- Tommy Dewey - Tommy Wheeler
- Heidi Fecht - Michelle Smith
- Marcy Goldman - Linda Grimshaw
- Janet Haley - Woman
- Aaron Hart - Jesse Smith
- Drew James - Young Tommy Wheeler
- Joel Johnstone - Van Hawkins
- Shannon Lucio - Tina Wheeler
- Tiz McWilliams - Cathy Duncan
- Betsy McIntyre - Windy Kennedy
- Tabitha Morella - Teen Girl
- Nichole Porges - Young Tina Wheeler
- J.J. Pyle - Alice Starrett
- Anna Roberts - Hilda Drake
- Michael Rooker - Chief Brad Carlson
- Michael Sidisin, Jr. - John Clayton
- A.J. Smitrovich - Rick Bradford
- Michael Villani - Chief Tom Schultz
- Aaron Hotchner: Tennessee Williams said, "We all live in a house on fire. No fire department to call, no way out."
- Aaron Hotchner: "I have loved to the point of madness; that which is called madness, that which to me, is the only sensible way to love." – Françoise Sagan
- Michael Rooker, who plays Chief Brad Carlson, had previously portrayed real-life serial killer Henry Lee Lucas in Henry: Portrait of a Serial Killer. Shannon Lucio, who plays Tina Wheeler, also portrayed spree killer Charles Starkweather's lover and accomplice, Caril Ann Fugate, in the 2004 film Starkweather.
- Heidi Fecht, the actress who portrayed Michelle Smith in this episode, previously appeared earlier in the season, starring as a concerned mother in Zoe's Reprise.
- ↑ Credited as "Mother"