Cibrian, an only child, was born in Burbank, California, the son of Hortensia, an office manager, and Carl Cibrian, a banker. He is of Cuban and Armenian origin.
Cibrian has starred in The Young and the Restless, Baywatch Nights, Sunset Beach as leading man Cole Deschanel, Third Watch as womanizing New York City firefighter Jimmy Doherty, Tilt as rising poker star Eddie Towne, and Invasion as Everglades park ranger Russell Varon. He has also guest-starred in Saved by the Bell: The College Years, Sabrina, the Teenage Witch, Criminal Minds and Beverly Hills, 90210. His movie credits include Living Out Loud, But I'm a Cheerleader, and The Cave.
In 2006, Cibrian joined the cast of the Fox series Vanished midway through the season and was named the lead star of the show after the original star Gale Harold left the series following the demise of his character in the series' seventh episode. Cibrian actually starred in the eighth episode, in which top-billed Harold appeared only as a corpse. He attained top billing in the following episode, which was the last to be broadcast before the network announced the show's cancellation. The remaining episodes were made available on streaming video at Myspace. The following year, he was cast as Jason Austin in the unaired pilot of Football Wives, the ABC remake of the largely successful British drama Footballers Wives.
Cibrian has since had guest spots on Samantha Who?, Dirty Sexy Money, and Ugly Betty. In 2009, he joined the cast of CSI: Miami as an officer from the Hollywood division who joins Horatio's team in Miami.