- Barnaby Barrilla - Elian Morales
- Toya A. Brown - Screaming Mom
- Chris Butler - Professor Hollis Walker, Jr.
- Rico Devereaux - Juan
- Michelle Gillette - Brenda
- Hakeem Kae-Kazim - Julio Ruiz
- Brian Kubach - Assistant
- Stephen Mendel - Doctor Barnes
- Grasie Mercedes - Ritual Woman
- Rachel Nichols - Agent Ashley Seaver
- Manny Perez - Manny
- Ruben Rabasa - Jimmy Mercado
- J. Santiago - Victor Cabrera
- Spencer Reid: "No man chooses evil because it is evil. He only mistakes it for happiness, the good he seeks." Mary Wollstonecraft Shelley
- Spencer Reid: "The best and most beautiful things in life cannot be seen or even touched. They must be felt with the heart." Helen Keller
- The word "corazón" is Spanish for "heart".