- Eddie Alfano - Frazier
- Diego Amarosa - Duerson
- Vivian Benitez - Lisa Jackson
- Aidan Bristow - Danny White
- Josh Drennen - Bartender
- Phillip Garcia - Luis Delgado
- Rawann Gracie - Young Danny White
- Alexander Harris - Officer Peters
- Marabina Jaimes - Newscaster
- Richard T. Jones - Officer Lionel Wilkins
- Wayne Lopez - Detective Baez
- Kandis Mak - Serena Adams
- Crystal-Lee Naomi - Gigi Stevens
- Tatum O'Neal - Miranda White
- Harold Perrineau - Calvin Shaw
- Tabitha Petrini - Sadie
- Peter James Smith - M.E. Wong
- "Knucklehead" by We-Are-Z
- "Waking Light" by Dwayne Shivers & Kyshona Armstrong
- Spencer Reid: "To go against conscience is neither right nor safe. Here I stand. I can do no other." Martin Luther
- Spencer Reid: "Hope is being able to see that there is light, despite all of the darkness." Desmond Tutu
- The episode's title seems to be a play on the term "Resistance is futile", a famous quote by the Borg, an alien race featured in Star Trek.
- This is the fifth of nine episodes to deal with two separate cases.
- ↑ Credited as "Guard #1"