The full version of the ending bookend quote by J. Robert Oppenheimer also includes a quote from the Hindu scripture Bhagavad Gita, which was recited several times during the episode (being erroneously attributed to having Oppenheimer as its original speaker and not the Bhagavad Gita), and a second quote of which was the episode's beginning bookend quote. In addition, the beginning bookend quote was recited by Oppenheimer as well, further strengthening the theme of the episode.
In further addition, the "Robot Boy" track used in the episode is sung by Linkin Park, whose fourth album is called "A Thousand Suns". The album focuses on themes of human fears revolving around nuclear warfare, which is addressed in the episode. Also, the ending bookend quote is used in the same album, specifically in the track called "The Radiance".
The character of suspect First Officer Frank Canvers seems to be partially based on Gameel Al-Batouti, who was disputed to have intentionally crashed the passenger jet he was flying, EgyptAir Flight 990, in a mass murder-suicide.
The episode was skipped in the Netherlands due to the plot's similarities to the Malaysia Airlines Flight 17 crash (since a majority of those dead were Dutch citizens). A rerun of the Season Nine episode The Return was aired instead. Later, on February 25, 2015, the episode aired for the first time in the country, preceded by a text reading, in Dutch, "This episode of Criminal Minds includes imagery that has similarities to the MH17-disaster. Viewer discretion is advised."