- Jayne Atkinson - FBI Section Chief Director Erin Strauss
- Edita Brychta - Mrs. Stanworth
- Philip Casnoff - James Stanworth
- Greg Collins - Detective Bill Codwin
- Joy Darash - Young Mary Rutka
- Megan Kathleen Duffy - Carrie Sanderson
- Nikki Hahn - Abby Sanderson
- Mike Hoagland - Young James Stanworth
- Chrys Ryan Johnson - Young Thomas Gregory Wittman
- Phil Levesque - Thomas Gregory Wittman
- Paula Mattioli - Mary Rutka
- Rachel Nichols - Agent Ashley Seaver
- Chris Prangley - Joshua Sanderson
- Kyle Secor - Donald Sanderson
- Derek Morgan: "There is no such thing as part freedom." Nelson Mandela
- Derek Morgan: "All truths are easy to understand once they are discovered; the point is to discover them." Galileo
- "25 to Life" refers to the maximum sentence if one is convicted of murder.
- In the scenes where Morgan talks one-on-one with Sanderson, the music of the same style as that in The Shawshank Redemption plays in the background.
- Greg Collins, the actor who portrays Detective Bill Codwin, previously appeared on Criminal Minds. He portrayed Captain Warner in the Season Four episode Mayhem.
- Despite being credited in the opening sequence, Thomas Gibson, the actor who portrays Hotch, doesn't appear in the episode and is only mentioned.