- Brian Appel - Agent Grant Anderson
- Jayne Atkinson - FBI Section Chief Director Erin Strauss
- Nicholas Brendon - Analyst Kevin Lynch
- Glenn Clark - Panel Member #1
- Max Goudsmit - Young EMT
- Zokai Holmes - FBI Agent/Super
- C. Thomas Howell - George Foyet
- Meredith Monroe - Haley Brooks
- Cade Owens - Jack Hotchner
- Gina Garcia Sharp - CSU Tech Agent Gina Sharp
- Josh Stewart - Detective William LaMontagne, Jr.
- D.B. Sweeney - U.S. Marshal Sam Kassmeyer
- Kim Swennen - Medic #1
- Ariana Thomas - Pharmacist
- Ty Vincent - Medic #2
- Aaron Hotchner: "He who fights with monsters might take care, lest he thereby become a monster. And if you gaze for long into an abyss, the abyss gazes also into you." – Friedrich Nietzsche
- Aaron Hotchner: Poet Haniel Long said, "So much of what is best in us is bound up in our love of family that it remains the measure of our stability because it measures our sense of loyalty."
- A similar version of Friedrich Nietzsche's quote was previously recited by Gideon as the ending bookend quote for Extreme Aggressor, the show's pilot episode.
- Another version of this quote was recited by JJ at the end of the 200th episode of the series, and so the quote can be seen as a frame.
- Zokai Holmes, the actor who portrays an undercover FBI agent, previously appeared on Criminal Minds, starring as a police sharpshooter in the Season Four episode Brothers in Arms.